Piroxicam (Feldene): What is it for?

Introduction to Piroxicam

Piroxicam (brand name: Feldene) is a non-steroidal anti-inflammatory drug (NSAID) that has been widely used to treat a variety of inflammatory and painful conditions.

In this article, we will address the mechanism of action, indications, presentations, dosage, contraindications, side effects, precautions and drug interactions of Piroxicam.

How does Piroxicam work?

Mechanism of action

Piroxicam/Feldene works by inhibiting the action of cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for the production of prostaglandins, substances that cause inflammation, pain and fever. By blocking the action of these enzymes, Piroxicam reduces symptoms associated with inflammatory conditions.

Mechanism of action Description
Inhibition of Prostaglandin Synthesis Piroxicam inhibits the enzyme cyclooxygenase (COX-1 and COX-2), responsible for the synthesis of prostaglandins, thus reducing the production of inflammatory substances.
Analgesic Action Reduced prostaglandin synthesis results in decreased pain and inflammation.
Antipyretic Action Piroxicam has a febrifuge action due to the inhibition of the synthesis of prostaglandins that control thermoregulation.

Anti-inflammatory, analgesic and antipyretic effects

Piroxicam has anti-inflammatory, analgesic (pain reduction) and antipyretic (fever reduction) effects, making it an effective choice in the treatment of a variety of conditions involving pain and inflammation.

Piroxicam main indications

Rheumatoid arthritis

Rheumatoid arthritis is a chronic, inflammatory disease that affects the joints, causing pain, swelling and stiffness. Piroxicam can be used in the treatment of this condition, helping to relieve pain and inflammation, as well as improving the mobility of affected joints.


Osteoarthritis is a degenerative condition that affects the joints and is characterized by loss of cartilage, causing pain and stiffness. Piroxicam is indicated to alleviate the pain and inflammation associated with osteoarthritis, providing symptom relief and a better quality of life for patients.

Acute pain and inflammation

Piroxicam can also be used to treat acute conditions such as sprains, strains, post-operative pain and other situations where pain and inflammation occur.

Presentations of Piroxicam


Piroxicam is available in the form of capsules, which must be taken orally with a glass of water. The dosage varies according to the condition being treated.

topical gel

Piroxicam gel is an option for the localized treatment of inflammatory and painful conditions such as muscle and joint pain. The gel should be applied to the affected area as per package directions.

injectable solution

In specific cases, Piroxicam can be administered via intramuscular injection. This route of administration is generally reserved for situations where the patient cannot take the medication orally or when rapid relief of pain and inflammation is needed.

Feldene dosage and administration

piroxicam dosage

general dosage

Piroxicam dosage varies depending on the condition being treated and the severity of the symptoms. It is important to follow the doctor’s advice and the instructions on the medicine leaflet.

Formulation dosage for adults
Pills 20 mg once a day
Suspension 10 mg/mL, 10 mL once a day
Capsules 20 mg once a day
Injection 10 mg/mL, 2 mL once daily

dose adjustment

In some cases, the doctor may adjust the dose of Piroxicam according to the patient’s response to the treatment. Always consult a healthcare professional before making any changes to your medication dosage.


Piroxicam is contraindicated for patients with hypersensitivity to Piroxicam or any component of the formula. It should also not be used by patients with a history of asthma, hives or other allergic reactions caused by NSAIDs.

Furthermore, it is contraindicated in patients with active peptic ulcer, gastrointestinal bleeding or severe renal, hepatic or cardiac insufficiency.

Side effects

Side effects of Piroxicam can include upset stomach, nausea, vomiting, diarrhea, dizziness, headache, fluid retention and skin rashes.

In rare cases, more serious side effects such as gastric ulcers, gastrointestinal bleeding, kidney failure and severe allergic reactions may occur.

If you experience any side effects, tell your doctor immediately.

Precautions and Warnings

piroxicam precaucao

Piroxicam should be used with caution in patients with a history of gastric, kidney, liver or heart disease, as well as in patients using anticoagulants, diuretics or other NSAIDs.

It is important to tell your doctor about all medications and supplements you are taking before starting Piroxicam treatment.

Drug interactions

Piroxicam may interact with other medications such as anticoagulants, antihypertensives, diuretics, corticosteroids, lithium and methotrexate. These interactions may increase the risk of side effects or reduce the effectiveness of the drugs involved.

Consult your doctor before starting or stopping any medication while using Piroxicam.

Pharmacological Interaction Effects
Piroxicam with aspirin Increased risk of stomach ulcers (reflux, gastritis, ulcers)
Piroxicam with non-steroidal anti-inflammatory drugs (NSAIDs) Increased risk of side effects such as gastric, kidney and liver damage
Piroxicam with anticoagulants Increased anticoagulant effect
Piroxicam with digoxin Increased blood levels of digoxin (increased risk of adverse effects)
Piroxicam with diuretics Increased diuretic effect (increased urine volume)
Piroxicam with cyclosporine Increased blood levels of cyclosporine
Piroxicam with methotrexate Increased toxic effect of methotrexate

Pregnancy and lactation

Piroxicam is not recommended during pregnancy, especially in the third trimester, as it can cause problems for the unborn baby. If you are pregnant or planning to become pregnant, consult your doctor before using Piroxicam.

It is not known whether Piroxicam is excreted in breast milk, therefore its use during breast-feeding should be discussed with the doctor.

Storage and disposal

Piroxicam should be stored in its original packaging, at room temperature, protected from light and moisture. Keep the medicine out of reach of children and pets. Do not use the medicine after the expiry date printed on the package.

If you have expired or no longer used medication, dispose of it correctly, following your local medication disposal guidelines.

Final considerations


Piroxicam is a non-steroidal anti-inflammatory drug that is effective in treating a variety of conditions involving pain and inflammation, such as rheumatoid arthritis and osteoarthritis. It is important to follow your doctor’s advice and package insert instructions to ensure safe and effective use of Piroxicam.

If you have any questions or concerns, consult your doctor or pharmacist.

FAQs – Frequently Asked Questions about Piroxicam

Is Piroxicam an over-the-counter medication?

No, Piroxicam is a medicine that requires a medical prescription for its purchase and use.

O Can Piroxicam be used in children?

The use of Piroxicam in children should be evaluated by the physician, as the safety and efficacy of the drug in pediatric patients have not been established.

Can I drive or operate machinery while taking Piroxicam?

Piroxicam can cause dizziness in some patients. If you experience dizziness or drowsiness, avoid driving or operating machinery until you feel safe to do so.

Can I drink alcohol while using Piroxicam?

Consumption of alcohol while taking Piroxicam may increase the risk of side effects such as gastrointestinal bleeding and gastric ulcers. Consult your doctor before consuming alcohol while taking Piroxicam

Can Piroxicam be used together with other pain relievers?

Concomitant use of Piroxicam with other analgesics, especially NSAIDs, may increase the risk of side effects. Consult your doctor before combining Piroxicam with other pain medications.

Source: blogdasaude.com.br

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