Mesigyna Injection Fattening? Learn More About This Contraceptive

Mesigyna is an injectable contraceptive consisting of a combination of two synthetic female hormones: estrogen and progesterone. By acting on the pituitary gland, it inhibits ovulation and alters the cervical mucus, making pregnancy impossible. Its effect is similar to other combined hormonal contraceptives.

Many women report weight gain after starting to use Mesigyna injectable contraceptive. However, studies do not prove this relationship. What can happen is a greater retention of liquids, causing the feeling of being more “fat”. It is worth noting that side effects vary from person to person.

When used correctly, the monthly contraceptive injection is a very effective method, with a failure rate of around seven in a thousand. To ensure effectiveness, the first injection must be applied within seven days of the onset of menstruation and then applied always on the same day every 30 days.

What is Mesigyna?

Mesigyna is an injectable contraceptive, administered intramuscularly. It contains two components: estrogen (estradiol) and progesterone (norethisterone). Norethisterone, which is the progesterone of Mesigyna, is more androgenic, that is, it is more associated with testosterone. If you have specific complaints, such as weight gain or acne, it may not be the right contraceptive for you.

The controversy about weight gain – does Mesigyna get fat?

According to statistics, monthly contraceptive injection does not cause weight gain. However, if you notice an increase in your weight after using a hormonal method, such as the IUD with hormone, vaginal ring, pill or injection, the recommendation is to talk to your doctor to assess whether it is worth suspending the method and using a non-hormonal method, such as a hormone-free IUD or condoms.

How to correctly apply Mesigyna?

The monthly contraceptive injection contains two hormones: an estrogen and a progesterone. The injection is given into the muscle and the hormone is released gradually over the month.

However, medicine and biochemistry are not exact sciences and it is not possible to accurately determine how much hormone will be absorbed each day. As a result, the menstrual cycle may not be as regular as some women prefer.

Mesigyna comes in a box with 1 vial of medicine, a syringe and a needle. It should be applied on the first day of your period. The application must be repeated every 30 days. If you forget to take it on the correct day, there is a gap between 27 and 33 days in which you can give the injection.

Mesigyna effects and symptoms

Side effects of Mesigyna include changes in the menstrual cycle, such as spotting between periods, prolonged bleeding or no periods, breast pain and headache.

Furthermore, androgenic progesterone may be associated with fluid retention, leading to an increased sense of weight gain.

Two other less common symptoms, but which can occur, are hair growth and acne.

Rarely, there may be increased levels of stress and nervousness. More rare and dangerous cases involve the development of blood clots, which can lead to deep vein thrombosis.

Advantages of using Mesigyna


The main advantages of Mesigyna include its high effectiveness, reduced risk of becoming pregnant (even lower than the risk after tubal ligation), practicality of monthly use and lower risk of forgetting compared to birth control pills.

In addition, the use of Mesigyna can regulate the menstrual cycle, decrease PMS, menstrual cramps and prevent ovarian and endometrial cancer.

Contraindications of Mesigyna

There are some contraindications for the use of Mesigyna, such as migraine with aura, age above 35 years, lupus, history of stroke, pulmonary thromboembolism, deep vein thrombosis, neoplasms (malignant tumors) in the liver, cirrhosis and neoplasms of the gynecological or breast tract .

If you cannot use Mesigyna, consult your gynecologist to evaluate another more suitable contraceptive method.

Mesigyna is contraindicated in cases of pregnancy or suspected pregnancy, cardiovascular disease, thrombosis, myocardial infarction, stroke, diabetes, migraine, liver disease or tumors. Women with a history of these conditions should seek other contraceptive options.

What to do if you forget to take your injection?

If you are unable to get the injection on the correct day, there is a small allowance of three days or so. However, it is essential to stay within this period to ensure the effectiveness of the method.


Mesigyna is an injectable contraceptive that is 99.7% effective, offering greater protection than oral contraceptives. Also, it is easier to use as it is only applied once every 30 days.

However, it is important to be aware of possible side effects and contraindications. Always consult your doctor to discuss the best contraceptive option for you.


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