Does Gabapentin Work for Anxiety? – Health Blog

Anxiety is a condition that affects many people, and proper symptom control is important to improve functionality, day-to-day life and quality of life. Anxiety treatment is multidisciplinary, and several medications can be used for its treatment.

Gabapentin is a drug best known for its use in the treatment of seizures, neuropathies and diabetic neuropathy, but it has also been used in clinical practice as a secondary option to treat mild anxiety.

The exact mechanisms by which Gabapentin acts on anxiety are still not fully understood, but its effect on the central nervous system is believed to play a key role. This medication works primarily on GABA receptors in the brain, increasing their effectiveness and helping to regulate brain activity. In doing so, Gabapentin may provide symptom relief for some anxious people.

It is worth mentioning that Gabapentin is not an officially approved medication for treating anxiety, and more research is needed to understand all its benefits and side effects in this context.

However, the effectiveness of Gabapentin in the treatment of anxiety disorders has already been demonstrated in some clinical studies, but it is important to consider each case individually and consult a specialist doctor before starting to use the drug.

What is Gabapentin?

Gabapentin is an anticonvulsant medication used primarily to control seizures in people with epilepsy. It is also known by the trade names Neurontin. In addition to its use in the treatment of epilepsy, Gabapentin is effective in the treatment of pain such as neuropathic pain, such as pain caused by herpes zoster (shingles), sciatica (pain from inflammation of the sciatic nerve), diabetic polyneuropathy (peripheral nerve inflammation from diabetes ).

Gabapentin is not considered an anti-anxiety medication like the benzodiazepines, but it has been studied for use in treating anxiety disorders. It works by increasing levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that decreases the electrical activity of neurons, helping to control seizures and possibly contributing to reduced anxiety.

There are generic versions of Gabapentin available in the market, which are usually more affordable than branded versions. The prescription of Gabapentin as part of a treatment plan should always be guided by a qualified physician, and its use should be monitored and adjusted according to the patient’s evolution.

What is Gabapentin used for?

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Treatment of Seizures

Gabapentin is an effective drug in the treatment of convulsive seizures, also called epileptic seizures. It acts on the brain in order to decrease the activity that can cause seizures, helping to control them in people with epilepsy.

Neuropathic pain

Furthermore, Gabapentin is effective in treating neuropathic pain, especially that caused by diabetes and herpes zoster. This type of pain is a result of nerve damage and can be characterized by:

  • severe pain
  • tremors
  • burning sensations

Gabapentin helps to reduce the intensity of pain and improve the patient’s quality of life.

Other Relevant Conditions

Gabapentin is also used in less common health conditions. These include:

  • Generalized anxiety and panic disorders: May ease anxiety symptoms such as agitation, stress, and panic attacks.
  • alcoholic abstinence: Gabapentin may help relieve withdrawal symptoms such as shakiness, nausea, vomiting, insomnia, and restlessness.
  • restless legs syndrome: May reduce restlessness and discomfort in patients with this condition.
  • sleep disorders: Gabapentin may help improve sleep quality by reducing insomnia and fatigue.
  • menopause symptoms: May decrease menopausal symptoms, including hot flashes and mood swings.

Although its use in some of these conditions is considered off-label, physicians may prescribe Gabapentin when its benefits outweigh the possible risks.

Is Gabapentin Good for Anxiety?

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Studies suggest that gabapentin may be effective in cases of generalized anxiety, social anxiety disorder and other forms of anxiety such as panic attacks.

Anxiety is a complex condition that can manifest itself in many ways, including generalized anxiety disorder (GAD), social anxiety disorder and panic attacks. People suffering from these disorders may experience symptoms such as excessive fear or worry, difficulty concentrating, fatigue, irritability, and muscle tension.

The use of gabapentin in the treatment of anxiety is considered “off-label”, that is, it does not have the approval of specific regulatory agencies for this purpose. However, this does not mean that the drug is ineffective in alleviating anxiety symptoms.

Several studies have investigated the use of gabapentin as a treatment option for anxiety, and many have shown promising results.

When analyzing the different types of anxiety:

  • Generalized anxiety: Studies show that gabapentin can help reduce the intensity of symptoms in patients with GAD.
  • Social anxiety disorder: There are indications that gabapentin is effective in the treatment of social anxiety disorder, improving the quality of life of patients.
  • Panic attacks: Although less studied for panic attacks, gabapentin has shown potential to alleviate the symptoms of this condition in some research.

It is important to talk to a doctor before starting treatment with gabapentin for anxiety. Only a qualified professional can assess the benefits and possible risks of the medicine and determine the appropriate dose.

Side Effects and Precautions

Common Side Effects

Gabapentin can cause a number of common side effects, including:

  • Nausea
  • Somnolence
  • Dizziness
  • Fatigue
  • Swelling
  • Weight gain
  • vomit
  • Diarrhea
  • Dry mouth

It is important to keep in mind that not all patients will experience these side effects, and some of them may disappear over time as the body adjusts to the medication.

Serious Side Effects

Some serious side effects of gabapentin include:

  • Suicidal thoughts
  • Depression
  • Fever
  • Agitation
  • Hallucinations
  • Insomnia
  • double vision
  • Memory loss
  • kidney problems
  • anaphylaxis

If any of these symptoms occur, it is crucial to seek medical attention immediately.


Gabapentin can interact with other medications such as lorazepam, increasing the risk of side effects.

Always tell your doctor about all medications and supplements you are taking to avoid unwanted interactions.

Dose and Administration

The dose and administration of gabapentin vary according to age, medical condition and response to treatment. Doctors usually start with a low dose and gradually increase it until they find the right dose for the patient. It is important to follow medical advice and not increase or decrease the dose without consulting your doctor.

The dose of gabapentin can vary from 300mg/day to 3600mg/day. The vast majority of adult patients receive treatment with doses between 1200mg/day and 1800mg/day.

Patients with kidney problems, especially those on dialysis, may need dosage adjustments. In addition, pregnant or breastfeeding women should inform their doctor, as gabapentin may pose a risk to the fetus or newborn.

In case of suspected overdose, seek medical attention immediately. Overdose symptoms include: extreme drowsiness, tiredness, slurred speech and weakness. It is important to use caution when administering gabapentin to prevent abuse or dependence.

When stopping the use of gabapentin, follow the doctor’s instructions, as the abrupt withdrawal of the drug can cause withdrawal effects, such as insomnia, nausea, headache and diarrhea.


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