Do I need to take Dorflex or Miorrelax on an empty stomach?

Dorflex is a medicine composed of three substances: dipyrone monohydrate (300 mg), orphenadrine citrate (35 mg) and anhydrous caffeine (50 mg) 2.

These components work together to provide relief from pain associated with muscle contractures, including tension headaches1.

  • Dipyrone is an analgesic and antipyretic, responsible for relieving pain1.
  • Orphenadrine citrate is a muscle relaxant, which helps reduce tension and discomfort caused by muscle contractures2.
  • Anhydrous caffeine enhances the analgesic effect of dipyrone, increasing its effectiveness in relieving pain2.

The onset of action of Dorflex occurs from 30 minutes after administration and can last up to 8 hours1.

It is important to follow medical instructions and the medication leaflet to ensure the appropriate and safe use of Dorflex.

Do I need to take Dorflex on an empty stomach?

It is not necessary to take Dorflex on an empty stomach. You can take the tablets with liquid (approximately ½ to 1 cup) orally.

Although Dorflex is not an anti-inflammatory, it can cause gastric irritation in some cases4. If you experience stomach discomfort after taking Dorflex or Miorrelax, it may be helpful to take the medication with food or milk to reduce the risk of stomach irritation.

However, it is important to follow medical advice and the dosage indicated in the medication leaflet2. If you have questions about taking Dorflex, consult your doctor or pharmacist for specific information about the proper use of the medication.

If you have ever had irritation or heartburn from using Dorflex

To prevent stomach irritation when taking Dorflex on an empty stomach, you can follow some guidelines:

  1. Take the medicine with liquid: Drink approximately ½ to 1 glass of water when taking Dorflex tablets.
  2. Eat a light meal before taking the medicine: Eating before taking Dorflex can help dilute gastric acid and protect the stomach walls.
  3. Avoid alcoholic beverages: Alcohol can irritate the stomach lining and worsen the effects of the medicine.

If you continue to experience stomach irritation while taking Dorflex, even after following these guidelines, consult your doctor or pharmacist for specific information about proper use of the medication and possible treatment adjustments.

Gastric Irritation Due to the Use of Dorflex

Constant Heartburn 3 1

1. Stomach Pain: The pain may manifest as a sharp, burning or cramping sensation in the upper abdomen, usually in the middle or left above the navel. In some cases, this pain may radiate to the upper back.

2. Stomach Discomfort: Stomach discomfort refers to a variety of sensations ranging from mild bloating to feelings of pressure or fullness, even when eating little.

3. Feeling of Full Stomach: Even after a light meal, a person may feel as if they have overeaten. This is a feeling of distension and fullness in the stomach.

Mechanism of action

Stomach irritation may occur due to substances contained in Dorflex that cause increased production of gastric acid, or due to the direct effect of the medication on the stomach lining. Increases in gastric acid production can lead to greater susceptibility to injury and inflammation of the stomach lining.


To minimize the risk of stomach irritation:

  • Always take Dorflex with a sufficient amount of water.
  • Consuming the medicine after a light meal can help reduce irritation, as the food can act as a type of “cushion”, minimizing direct contact of the medicine with the stomach lining.
  • If symptoms persist or become severe, it is advisable to consult a doctor. It may be necessary to adjust the dose, change the medication, or consider other therapies.


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