Antiallergic Drugs That Cause Sleepiness: Get to Know The Main Ones

Os antiallergic are medications used to combat allergy symptoms and related illnesses.

Thus, they are divided into two main groups: the first generation antiallergic and second-generation antiallergics.

The first-generation ones have been on the market for a longer time and were the first remedies developed to combat allergic processes.

In general, at the time they were developed, the pharmaceutical industry was not as developed as it is today.

For this reason, they cause several side effects, among the most common drowsiness and sedation.

In this article, you will learn about the antiallergic drugs that make you sleepy and those that do not usually cause the effect.

List of antiallergics that can cause drowsiness

In general, antiallergic drugs that make you sleepy have some components in the formula, such as:

  1. Promethazine: Promethazine Hydrochloride, Phenergan and Profergan
  2. Hydroxyzine: Hixizine, Pergo, Cloridrato de Hydroxizine e Pruri-gran
  3. Dexchlorpheniramine: Histamine, Polaramine Allergomine, Alermine, Fenirax, Dexlerg
  4. Clemastina: I bought, Agasten, Fumarato de Clemastina
  5. Diphenhydramine: Diphenidrine, Adnax, Notuss

Due to the fact that they make drowsiness, these drugs are often called sedative antiallergic.

In addition, it is common to find people who resort to these drugs to improve sleep and eliminate insomnia.

However, this practice is not recommended, as most first-generation antiallergics tend to have some side effect.

Mechanism of action

Anti-allergic drugs that make you sleepy has an ability to overcome the blood-brain barrierregion that is responsible for protecting the excess passage of substances from the blood to the central nervous system.

With this, the active principle of these drugs ends up blocking the action of histamine.

A histamine it is a biochemical marker produced in situations of stress or when the immune system is compromised.

In this way, the antiallergic drugs that make you sleepy prevent it from carrying out its functions, among which are:

  • Promote alertness and concentration
  • Vasodilation
  • mucus secretion
  • bronchoconstriction
  • Produce allergic signs and symptoms
Antiallergics that cause the sound 2 1

Still, From the moment the first-generation antihistamines act, they produce effects such as:

  • Sedation
  • Somnolence
  • Tiredness
  • Fatigue
  • Concentration reduction
  • Sleep cycle changes

As allergic processes can be serious in many cases, antiallergic drugs that make you sleepy are the best alternative for treating this condition.

However, people’s cognitive and alert capacity is compromised with the use of such drugs.

In addition, there are studies that associate the use of first-generation antiallergic drugs with the same symptoms related to excess alcohol, such as hangover, dizziness, nausea and vomiting.

Although they are still widely used today, anti-allergic drugs that make you sleepy are gradually being replaced by anti-allergic drugs that don’t make you sleepythe so-called second- and third-generation antihistamines.

List of antiallergics that do not usually cause drowsiness

Antiallergic drugs that do not usually cause drowsiness have greater affinity with peripheral H1 receptors. In practice, this means that they they cannot “invade the central nervous system”.

So, they promote reduction and in some cases elimination of the sedative effects that include drowsiness and inattention. The main antiallergics that do not cause drowsiness are:

Derivatives of Loratadine

  • Claritin
  • Loratamed
  • Lorasliv
  • Neo Loratadin
  • Histidine
  • Cloratadd
  • Loritil
  • Allergaliv

Cetirizine Derivatives

  • Zyrtec
  • Zetalerg
  • tools
  • Cetirtec

Derivatives of Desloratadine

  • Desalex
  • Esalerg
  • Aloff
  • Leg
  • Aleradina
  • Sigma life

Levocetirizine Derivatives

  • Other
  • Zyxem
  • Rice
  • Vocety
  • Ucitir

Derived from Bilastine

Fexofenadine derivatives

  • Allegra
  • Fexodane
  • Allexofedrin
  • Fexx
  • haughty



But beware, every rule has its exceptions.

Although second- and third-generation antihistamines do not make the vast majority of people sleepy, it is not possible to state that these effects will be guaranteed to the entire population.

This means that a small number of users of these drugs may experience drowsiness. For this reason, it is not safe to say with certainty that these drugs do not cause sleep.

Furthermore, in the package inserts for all of them, drowsiness is listed as a less common possible side effect.

Why do some antiallergics have the letter D after the name?

There are remedies that are found in combination with other medications, where they are used to treat different symptoms at the same time.

For example, in the treatment of nasal unclogging, it is common for the health professional to prescribe an antiallergic that also has a systemic vasoconstrictor in the same formula as pseudoephedrine.

Therefore, when finding a medicine with the letter D after the name it means that the medicine contains different active principles for the treatment of several unrelated symptoms at the same time.

In the case of antiallergic drugs that do not usually cause drowsiness, the most common examples are Claritin D, Allegra D and Esalerg D.

Which is more effective: first or second generation antiallergic?

You must be wondering which antiallergic line is the best for your health. According to most of the world’s scientific communities, second-generation antiallergics are more effective than first-generation ones.

In addition, these drugs are used in licensed doses, that is, in small doses most of the time.

In turn, second- and third-generation antiallergics should not be used in high doses, known as “off-label”.

Finally, in some chronic allergic conditionsantiallergic drugs should be used as a form of prevention and not just after the onset of symptoms.

Antiallergics that cause the sound 1

Among the health problems that may need continuous use of second and third generation anti-allergy drugs are:

  • chronic urticaria
  • severe bronchial asthma
  • Eczema
  • Rhinitis
  • nasal polyps

Foods that fight allergies and related symptoms

There are some foods that can reduce the effects of allergy on the bodywhether due to the existence of vitamins or natural anti-allergic compounds.

Therefore, if you have a recurrent or chronic allergic problem and want to reduce the impacts caused on the body, some foods are beneficial, such as:

  • Salsa
  • Litter
  • Avocado
  • Broccoli
  • Onion
  • Garlic
  • Cabbage
  • Orange
  • Kiwi
  • Egg yolk
  • Natural yogurt
  • Red fruits
  • Mint
  • Probiotics sachet
  • Pineapple

Antiallergic drugs that make you sleepy: Frequently Asked Questions

Which anti-allergy makes you sleepy?

Histamin and Polaramine are two antiallergics that make most people sleepy when using them.

What is the duration of drowsiness caused by anti-allergic drugs?

In general, drowsiness caused by anti-allergic drugs that make you sleepy lasts from 24 to 48 hours, depending on the amount ingested.


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